Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
Identifieur interne : 000925 ( Main/Exploration ); précédent : 000924; suivant : 000926Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
Auteurs : Davide Corti [Suisse] ; Jincun Zhao [République populaire de Chine] ; Mattia Pedotti [Suisse] ; Luca Simonelli [Suisse] ; Sudhakar Agnihothram ; Craig Fett ; Blanca Fernandez-Rodriguez [Suisse] ; Mathilde Foglierini [Suisse] ; Gloria Agatic [Suisse] ; Fabrizia Vanzetta [Suisse] ; Robin Gopal [Royaume-Uni] ; Christopher J. Langrish [Royaume-Uni] ; Nicholas A. Barrett [Royaume-Uni] ; Federica Sallusto [Suisse] ; Ralph S. Baric ; Luca Varani [Suisse] ; Maria Zambon [Royaume-Uni] ; Stanley Perlman ; Antonio Lanzavecchia [Suisse]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Abstract
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe respiratory disease with a high mortality rate. There is no licensed vaccine or antiviral for MERS. Here we isolated for the first time, to our knowledge, a potent MERS-CoV–neutralizing antibody from memory B cells of an infected individual. This antibody binds to a novel site on the viral Spike protein, neutralizes by interfering with the binding to the cellular receptor CD26, and is highly effective both in prophylaxis and in therapy in a relevant mouse model. This antibody can be developed for prophylaxis, for postexposure prophylaxis, or for the treatment of severe MERS-CoV infections.
Url:
DOI: 10.1073/pnas.1510199112
PubMed: 26216974
PubMed Central: 4547275
Affiliations:
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first="Jincun" last="Zhao">Jincun Zhao</name><affiliation><nlm:aff id="aff3">Department of Microbiology,<institution>University of Iowa</institution>, Iowa City,<addr-line>IA</addr-line> 52240;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease,<institution>The First Affiliated Hospital of Guangzhou Medical University</institution>, Guangzhou 510120,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pedotti, Mattia" sort="Pedotti, Mattia" uniqKey="Pedotti M" first="Mattia" last="Pedotti">Mattia Pedotti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simonelli, Luca" sort="Simonelli, Luca" uniqKey="Simonelli L" first="Luca" last="Simonelli">Luca Simonelli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Fernandez Rodriguez, Blanca" sort="Fernandez Rodriguez, Blanca" uniqKey="Fernandez Rodriguez B" first="Blanca" last="Fernandez-Rodriguez">Blanca Fernandez-Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foglierini, Mathilde" sort="Foglierini, Mathilde" uniqKey="Foglierini M" first="Mathilde" last="Foglierini">Mathilde Foglierini</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agatic, Gloria" sort="Agatic, Gloria" uniqKey="Agatic G" first="Gloria" last="Agatic">Gloria Agatic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Humabs BioMed SA</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vanzetta, Fabrizia" sort="Vanzetta, Fabrizia" uniqKey="Vanzetta F" first="Fabrizia" last="Vanzetta">Fabrizia Vanzetta</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Humabs BioMed SA</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name><affiliation wicri:level="1"><nlm:aff id="aff6">Microbiology Services Colindale,<institution>Public Health England</institution>, London NW9 5HT,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langrish, Christopher J" sort="Langrish, Christopher J" uniqKey="Langrish C" first="Christopher J." last="Langrish">Christopher J. 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Baric</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Varani, Luca" sort="Varani, Luca" uniqKey="Varani L" first="Luca" last="Varani">Luca Varani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation wicri:level="1"><nlm:aff id="aff6">Microbiology Services Colindale,<institution>Public Health England</institution>, London NW9 5HT,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation><nlm:aff id="aff3">Department of Microbiology,<institution>University of Iowa</institution>, Iowa City,<addr-line>IA</addr-line> 52240;</nlm:aff></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10">Institute of Microbiology,<institution>Eidgenössische Technische Hochschule Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26216974</idno><idno type="pmc">4547275</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547275</idno><idno type="RBID">PMC:4547275</idno><idno type="doi">10.1073/pnas.1510199112</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000021</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000021</idno><idno 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wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Humabs BioMed SA</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation><nlm:aff id="aff3">Department of Microbiology,<institution>University of Iowa</institution>, Iowa City,<addr-line>IA</addr-line> 52240;</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease,<institution>The First Affiliated Hospital of Guangzhou Medical University</institution>, Guangzhou 510120,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pedotti, Mattia" sort="Pedotti, Mattia" uniqKey="Pedotti M" first="Mattia" last="Pedotti">Mattia Pedotti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simonelli, Luca" sort="Simonelli, Luca" uniqKey="Simonelli L" first="Luca" last="Simonelli">Luca Simonelli</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Fernandez Rodriguez, Blanca" sort="Fernandez Rodriguez, Blanca" uniqKey="Fernandez Rodriguez B" first="Blanca" last="Fernandez-Rodriguez">Blanca Fernandez-Rodriguez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foglierini, Mathilde" sort="Foglierini, Mathilde" uniqKey="Foglierini M" first="Mathilde" last="Foglierini">Mathilde Foglierini</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agatic, Gloria" sort="Agatic, Gloria" uniqKey="Agatic G" first="Gloria" last="Agatic">Gloria Agatic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Humabs BioMed SA</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vanzetta, Fabrizia" sort="Vanzetta, Fabrizia" uniqKey="Vanzetta F" first="Fabrizia" last="Vanzetta">Fabrizia Vanzetta</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Humabs BioMed SA</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name><affiliation wicri:level="1"><nlm:aff id="aff6">Microbiology Services Colindale,<institution>Public Health England</institution>, London NW9 5HT,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Langrish, Christopher J" sort="Langrish, Christopher J" uniqKey="Langrish C" first="Christopher J." last="Langrish">Christopher J. Langrish</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Guy’s and St. Thomas’ National Health Service Foundation Trust</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barrett, Nicholas A" sort="Barrett, Nicholas A" uniqKey="Barrett N" first="Nicholas A" last="Barrett">Nicholas A. Barrett</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Guy’s and St. Thomas’ National Health Service Foundation Trust</institution>, London SE1 7EH,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>King’s College London, Strand</institution>, London WC2R 2LS,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation><nlm:aff id="aff5">Department of Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill,<addr-line>NC</addr-line> 27599;</nlm:aff></affiliation></author><author><name sortKey="Varani, Luca" sort="Varani, Luca" uniqKey="Varani L" first="Luca" last="Varani">Luca Varani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name><affiliation wicri:level="1"><nlm:aff id="aff6">Microbiology Services Colindale,<institution>Public Health England</institution>, London NW9 5HT,<country>United Kingdom</country>;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation><nlm:aff id="aff3">Department of Microbiology,<institution>University of Iowa</institution>, Iowa City,<addr-line>IA</addr-line> 52240;</nlm:aff></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:aff id="aff1">Immune Regulation Unit, Institute for Research in Biomedicine,<institution>Università della Svizzera Italiana</institution>, 6500 Bellinzona,<country>Switzerland</country>;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10">Institute of Microbiology,<institution>Eidgenössische Technische Hochschule Zurich</institution>, 8093 Zurich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe respiratory disease with a high mortality rate. There is no licensed vaccine or antiviral for MERS. Here we isolated for the first time, to our knowledge, a potent MERS-CoV–neutralizing antibody from memory B cells of an infected individual. This antibody binds to a novel site on the viral Spike protein, neutralizes by interfering with the binding to the cellular receptor CD26, and is highly effective both in prophylaxis and in therapy in a relevant mouse model. This antibody can be developed for prophylaxis, for postexposure prophylaxis, or for the treatment of severe MERS-CoV infections.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suisse</li></country></list><tree><noCountry><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></noCountry><country name="Suisse"><noRegion><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name></noRegion><name sortKey="Agatic, Gloria" sort="Agatic, Gloria" uniqKey="Agatic G" first="Gloria" last="Agatic">Gloria Agatic</name><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name><name sortKey="Fernandez Rodriguez, Blanca" sort="Fernandez Rodriguez, Blanca" uniqKey="Fernandez Rodriguez B" first="Blanca" last="Fernandez-Rodriguez">Blanca Fernandez-Rodriguez</name><name sortKey="Foglierini, Mathilde" sort="Foglierini, Mathilde" uniqKey="Foglierini M" first="Mathilde" last="Foglierini">Mathilde Foglierini</name><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><name sortKey="Pedotti, Mattia" sort="Pedotti, Mattia" uniqKey="Pedotti M" first="Mattia" last="Pedotti">Mattia Pedotti</name><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><name sortKey="Simonelli, Luca" sort="Simonelli, Luca" uniqKey="Simonelli L" first="Luca" last="Simonelli">Luca Simonelli</name><name sortKey="Vanzetta, Fabrizia" sort="Vanzetta, Fabrizia" uniqKey="Vanzetta F" first="Fabrizia" last="Vanzetta">Fabrizia Vanzetta</name><name sortKey="Varani, Luca" sort="Varani, Luca" uniqKey="Varani L" first="Luca" last="Varani">Luca Varani</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Gopal, Robin" sort="Gopal, Robin" uniqKey="Gopal R" first="Robin" last="Gopal">Robin Gopal</name></noRegion><name sortKey="Barrett, Nicholas A" sort="Barrett, Nicholas A" uniqKey="Barrett N" first="Nicholas A" last="Barrett">Nicholas A. Barrett</name><name sortKey="Barrett, Nicholas A" sort="Barrett, Nicholas A" uniqKey="Barrett N" first="Nicholas A" last="Barrett">Nicholas A. Barrett</name><name sortKey="Langrish, Christopher J" sort="Langrish, Christopher J" uniqKey="Langrish C" first="Christopher J." last="Langrish">Christopher J. Langrish</name><name sortKey="Zambon, Maria" sort="Zambon, Maria" uniqKey="Zambon M" first="Maria" last="Zambon">Maria Zambon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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